Hematology analyzers are used to quickly and accurately count and identify blood cells. White blood cell counts, complete blood counts, reticulocyte analysis, and coagulation tests are all done with them in the medical sector. Hematology analyzers are available for both human and animal blood, making them helpful for veterinarians, zoos, and research facilities. A complete blood count (CBC) with a three-part differential and a five-part differential white blood cell (WBC) count is returned by basic analyzers. To diagnosis unusual blood diseases, sophisticated analyzers assess cell morphology and can detect small cell populations.
Electrical impedance, flow cytometry, and fluorescent flow cytometry are the three basic physical technologies utilized in hematology analyzers. To extend the observable parameters, these are used with chemical reagents that lyse or change blood cells. Electrical impedance, for example, may distinguish red blood cells (RBCs), white blood cells (WBCs), and platelets based on their volume. It is feasible to separate lymphocytes by volume by adding a nucleating chemical that shrinks lymphocytes more than other WBCs.
Basically there are two main types of hematology analyzer:
A). Three- part differential hematology analyzer- A 3-part differential cell counter uses Coulter's Principle to find the size and volume of the cell. A three-part hematology instrument is sufficient for most physician office laboratories. The neutrophil, monocyte, and lymphocyte counts on a simple CBC will reveal whether you have a viral illness or a bacterial infection that can be treated with antibiotics.
B). Five- part differential hematology analyzer- A 5-part differential hematology instrument uses flow cytometry to divide white blood cells (WBC) into five primary sub-populations depending on cell size and complexity (granularity): neutrophils, lymphocytes, monocytes, eosinophils, and basophils.
Apart from these two, Recent automated hematology analyzers also come with 6-part differential. They can identify immature granulocytes (IG) as a sixth population and report them as a proportion of total WBC count as well as an absolute count. Increased bone marrow activation, as observed in sepsis, is indicated by the presence of IG in peripheral blood. They also provide information on reticulocytes, nucleated RBCs, and fluorescent platelet counts, among other things, which are employed for a variety of clinical purposes.
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A). Erba Mannheim- Erba offers 3 part and 5 part differential analyzers in Hematology. The state-of-the-art analyzers are configured and customized for laboratories catering to a high workload. These analyzers are used to enumerate exclusive clinical parameters in addition to the conventional parameters enumerated. With up to 80 samples per hour, 20 µl sampling volume, Whole blood, capillary blood and prediluted and Reagent inventory management thru RFID Erba ELite 580 hematology analyzer is one top choice of doctors.
B). Sysmex- It is a global leader in clinical hematology analyzers. With its simplified operation, the XP-300 is an ideal hematology analyzer for a clinic satellite laboratory. It provides a CBC with 8 reportable parameters and 3-part WBC Differential, which includes an Absolute Neutrophil Count (ANC).
C). Mindray- Mindray is a well-known brand in the medical industry. Their advanced BC-6800Plus cell counter not only provides more reliable routine CBC plus 5-part DIFF results, but also has a higher throughput of up to 200 samples per hour. Based on the new SF Cube technology platform, the BC-6800Plus could provide more reliable blood cell results and abnormal cells flagging results with anticipated warning messages, exceeding clinicians’ expectations and setting a new standard for blood analysis is considered as one top choice of doctors and for hospitals use as well.
